Wellbutrin XL NDA 21-515

818 WELLBUTRIN XL has not been studied in children under the age of 18 years.

819

820 How should I take WELLBUTRIN XL?

821 ● Take WELLBUTRIN XL exactly as prescribed by your doctor.

822 ● Do not chew, cut, or crush WELLBUTRIN XL tablets. You must swallow the tablets

823 whole. Tell your doctor is you cannot swallow medicine tablets.

824 ● Take WELLBUTRIN XL at the same time each day.

825 ● Take your doses of WELLBUTRIN XL at least 24 hours apart.

826 ● You may take WELLBUTRIN XL with or without food.

827 ● If you miss a dose, do not take an extra tablet to make up for the dose you forgot. Wait and

828 take your next tablet at the regular time. This is very important. Too much WELLBUTRIN

829 XL can increase your chance of having a seizure.

830 ● If you take too much WELLBUTRIN XL, or overdose, call your local emergency or

831 poison control center right away.

832 ● The WELLBUTRIN XL tablet is covered by a shell that slowly releases the medicine inside

833 your body. You may notice something in your stool that looks like a tablet. This is normal.

834 This is the empty shell passing from your body.

835 ● Do not take any other medicines while using WELLBUTRIN XL unless your doctor has

836 told you it is okay.

837 ● It may take several weeks for you to feel that WELLBUTRIN XL is working. Once you fell

838 better, it is important to keep taking WELLBUTRIN XL exactly as directed by your doctor.

839 Call your doctor is you do not feel WELLBUTRIN XL is working for you.

840 ● Do not change your dose or stop taking WELLBUTRIN XL without talking with your doctor

841 first.

842

843 What should I avoid while taking WELLBUTRIN XL?

844 ● Do not drink a lot of alcohol while taking WELLBUTRIN XL. If you usually drink a lot of

845 alcohol, talk with your doctor before suddenly stopping. If you suddenly stop drinking

846 alcohol, you may increase your chance of having seizures.

847 ● Do not drive a car or use heavy machinery until you know how WELLBUTRIN XL affects

848 you. WELLBUTRIN XL can impair your ability to perform these tasks.

849

850 What are possible side effects of WELLBUTRIN XL?

851 ● Seizures. Some patients get seizures while taking WELLBUTRIN XL. If you have a seizure

852 while taking WELLBUTRIN XL, stop taking the tablets and call your doctor right

853 away. Do not take WELLBUTRIN XL again if you have a seizure.

854 ● Hypertension (high blood pressure). Some patients get high blood pressure, sometimes

855 severe, while taking WELLBUTRIN XL. The chance of high blood pressure may be

856 increased if you also use nicotine replacement therapy (for example, a nicotine patch) to help

857 you stop smoking.

858 ● Severe allergic reactions. Stop WELLBUTRIN XL and call your doctor right away if

859 you get a rash, itching, hives, fever, swollen lymph glands, painful sores in the mouth or