9h

323U66 HCl (mg/kg/day, po)

0

75

150

300

300^b

VISCERAL VARIATIONS

Total No. of Fetuses Examined for Visceral  Malformations^c

222

192

209

190

168

No. of Fetuses with Visceral Malformations^d

194

172

191

173

152

% Fetuses with Visceral Malformations

87.4%

89.6%

91.4%

91.1%

90.5%

Total No. of Litters Examined for Visceral Malformations^e

29

27

27

25

24

No. of Litters with Visceral Variations^f

29

27

27

25

24

% Litters with Visceral Variations

100.0%

100.0%

100.0%

100.0%

100.0%

Enlarged Lateral Ventricle (Full):           Bilateral

44 (16)

34(17)

34(16)

48(18)

33(17)

                                                                    Left

9(7)

7(4)

6(5)

6(3)

4(4)

                                                                    Right

6(4)

7(5)

8(7)

8(7)

Enlarged Lateral Ventricle (Half):           Bilateral

39(19)

39(19)

49(21)

39(16)

28(14)

                                                                    Left

2(2)

2(2)

4(4)

3(3)

                                                                    Right

7(6)

8(5)

3(3)

9(6)

5(5)

Enlarged Lateral Ventricle (Partial):       Bilateral

85(24)

76(25)

54(23)

76(23)

68(23)

                                                                    Left

5(4)

9(7)

6(6)

1(1)

5(5)

                                                                    Right

4(4)

6(6)

1(1)

5(5)

Distended Ureter:     Bilateral

1(1)

2(2)

1(1)

1(1)

                                    Left    

3(3)

3(3)

1(1)

2(2)

2(2)

                                    Right

2(2)

2(2)

1(1)

1(1)

SKELETAL VARIATIONS

Total No. of Fetuses Examined for Skeletal Variations^c

443

384

419

376

336

No. of Fetuses with Skeletal Variations^d

17

10

9

9

10

% Fetuses with Skeletal Variations

3.8%

2.6%

2.1%

2.4%

3.0%

Total No. of Litters Examined for Skeletal Variations^e

29

27

27

25

24

No. of Litters with Skeletal Variations^f

12

7

5

8

6

% Litters with Skeletal Variations

41.4%

25.9%

18.5%

32.0%

20.8%

Rib on Lumber 1:      Bilateral Full

1(1)

                                    Bilateral Rudimentary

2(2)

1(1)

2(1)

1(1)

                                    Left Full

1(1)

                                    Left Rudimentary

4(3)

3(3)

1(1)

1(1)

                                    Right Rudimentary

4(3)

3(2)

1(1)

1(1)

1(1)

Short Ribs:    XVII

1(1)

Wavy Rib

1(1)

1(1)

Normal Cartilage, Bipartite Ossification Center:

                        Thoracic Centrum

2(2)

4(4)

7(4)

3(3)

5(3)

Dumbbell Cartilage, Normal Ossification Center:

                        Thoracic Centrum

1(1)

Dumbbell Cartilage, Dumbbell Ossification Center:

                        Thoracic Centrum

3(3)

1(1)