|
|
9g |
65C-3883
45
Table 7. Morphological
Defects Observed in CD Rat Fetuses (continued)
|
|
323U66 HCl (mg/kg/day, po) |
||||
|
|
0 |
75 |
150 |
300 |
300b |
|
SKELETAL
MALFORMATIONS |
|||||
|
Total
No. of Fetuses Examined for Skeletal Malformationsc |
443 |
384 |
419 |
376 |
336 |
|
No.
of Fetuses with Skeletal Malformationsd |
0 |
0 |
0 |
0 |
1 |
|
%
Fetuses with Skeletal Malformations |
0.0% |
0.0% |
0.0% |
0.0% |
0.3% |
|
Total
No. of Litters Examined for Skeletal Malformationse |
29 |
27 |
27 |
25 |
24 |
|
No.
of Litters with Skeletal Malformationsf |
0 |
0 |
0 |
0 |
1 |
|
%
Litters with Any Malformations |
0.0% |
0.0% |
0.0% |
0.0% |
4.2% |
|
Bipartite
Cartlidge, Dumbbell Ossification Cetner: Therodic
Centrum |
|
|
|
|
1(1) |
|
|
|
|
|
|
|
|
ANY
VARIATIONS |
|
|
|
|
|
|
Total
No. of Fetuses Examined for Any Variationsc |
443 |
384 |
419 |
376 |
336 |
|
No.
of Fetuses with Any Malformationsd |
202 |
178 |
197 |
178 |
158 |
|
%
Fetuses with Any Malformations |
45.6% |
48.4% |
47.0% |
47.3% |
47.0% |
|
Total
No. of Litters Examined for Any Malformationse |
29 |
27 |
27 |
25 |
24 |
|
No.
of Litters with Any Malformationsf |
29 |
27 |
27 |
25 |
24 |
|
%
Litters with Any Malformations |
100.0% |
100.0% |
100.0% |
100.0% |
100.0% |
|
|
|
|
|
|
|
|
EXTERNAL
VARIATIONS |
|
|
|
|
|
|
Total
No. of Fetuses Examined for External Variationsc |
443 |
384 |
419 |
376 |
336 |
|
No.
of Fetuses With External Variationsd |
0 |
0 |
0 |
2 |
0 |
|
%
Fetuses with External Variations |
0.0% |
0.0% |
0.0% |
0.5% |
0.0% |
|
Total
No. Litters Examined for External Variationse |
29 |
27 |
27 |
25 |
24 |
|
No.
of Litters with External Variationsf |
0 |
0 |
0 |
2 |
0 |
|
%
Litters with Visceral Malformations |
0.0% |
0.0% |
0.0% |
8.0% |
0.0% |
|
Hematoma: Neck |
|
|
|
2(2) |
|
(continued)
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