Table
9. Pharmacokinetics Parameters for Bupropion and 306U73 in Rats on
Day
82 Following an Oral Administration of Bupropion (TOX 648)
|
|
|
Bupropion |
306U73 |
||||
|
|
Gender |
AUC (ng/ml. hr) |
Cmax (ng/ml.) |
Tmax (hr) |
AUC (ng/ml. hr) |
Cmax (ng/ml.) |
Tmax (hr) |
|
GROUP 6 |
|
|
|
|
|
|
|
|
75 mg/kg/day |
males |
966 |
545 |
0.5 |
325 |
133 |
0.5 |
|
(with impurities) |
|
|
|
|
|
|
|
|
|
females |
2469 |
1032 |
0.5 |
473 |
159 |
0.5 |
|
GROUP 7 |
|
|
|
|
|
|
|
|
150 mg/kg/day |
males |
1410 |
1001 |
0.5 |
415 |
186 |
0.5 |
|
(with impurities) |
|
|
|
|
|
|
|
|
|
females |
3443 |
1529 |
0.5 |
613 |
194 |
4 |
|
GROUP 8 |
|
|
|
|
|
|
|
|
300 mg/kg/day |
males |
7188a |
6577a |
0.5 |
715 |
411 |
0.5 |
|
(with impurities) |
|
|
|
|
|
|
|
|
|
females |
4662 |
2032 |
0.5 |
747 |
232 |
4 |
|
GROUP 9 |
|
|
|
|
|
|
|
|
300 mg/kg/day |
males |
1294 |
752 |
0.5 |
436 |
187 |
0.5 |
|
(without impurities) |
|
|
|
|
|
|
|
|
|
females |
6994 |
3810 |
0.5 |
1018 |
366 |
4 |
a includes outlying values
for rat 93-6128. Omitting the outlier
yields an AUC of 1061 ng/ml hr and a Cmax of 470 mg/ml.
TBZZ/93/0063 19
100
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