Table
8. Pharmacoidentic Parameters for Bupropion and 306U73 in Rats on
Day
10 Following an Oral Administration of Bupropion (TOX 648)
|
|
|
Bupropion |
306U73 |
||||
|
|
Gender |
AUC (ng/ml. hr) |
Cmax (ng/ml.) |
Tmax (hr) |
AUC (ng/ml. hr) |
Cmax (ng/ml.) |
Tmax (hr) |
|
GROUP 6 |
|
|
|
|
|
|
|
|
75 mg/kg/day |
males |
287 |
279 |
1.0 |
258 |
162 |
1.0 |
|
(with impurities) |
|
|
|
|
|
|
|
|
|
females |
2302 |
1365 |
1.0 |
825 |
340 |
1.0 |
|
GROUP 7 |
|
|
|
|
|
|
|
|
150 mg/kg/day |
males |
432 |
362 |
1.0 |
452 |
301 |
1.0 |
|
(with impurities) |
|
|
|
|
|
|
|
|
|
females |
2626 |
2811 |
1.0 |
958 |
398 |
1.0 |
|
GROUP 8 |
|
|
|
|
|
|
|
|
300 mg/kg/day |
males |
335 |
226 |
1.0 |
666 |
277 |
1.0 |
|
(with impurities) |
|
|
|
|
|
|
|
|
|
females |
|
|
1.0 |
|
|
1.0 |
|
GROUP 9 |
|
|
|
|
|
|
|
|
300 mg/kg/day |
males |
2839 |
2181 |
1.0 |
3026 |
1707 |
1.0 |
|
(without impurities) |
|
|
|
|
|
|
|
|
|
females |
2064 |
1182 |
1.0 |
1574 |
745 |
1.0 |
TBZZ/93/0063 18
100
TTEP/93/0061 866
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