Mucopolysaccharidosis
- Degenerative developmental disease involving the
grey matter
- aka Hunter's, Hurler's, Sanfilipo Diseases
- generalized visceral involvement including the central nervous system (CNS)
- involves an accumulation of glycosamino glycans, including dermatan and
heparan sulphate
- variety of enzymes involved
- mutations, deletions and insertions on a wide variety of chromosomes