Abitur/Baccalaureat 1983 Mean: 1.2 on a scale from
1.0 to 6.0 (Top <1%)
Volontary Service 1982-91 Member of THW(Technisches Hilfwerk)
Medical School 1983-89 University of Heidelberg
M.D. Thesis 1986-90 Cloning
of murine Lamin C gene
Postdoctoral 1989-91 Retroviral
gene transfer in brain transplants
1991-94 Specific mutation of CD44 gene
Approbation 1992
Registration as a Doctor
Journeys/Stipends 1995/6 USA, Greece, Spain,
France, Switzerland
Postdoctoral 1997-99 New
metastasis flow chamber model
Scientific Interests Metastasis,
Tumorbiology, Chemokines,
Foreign Languages
English, French, Latin (big Latinum), Spanish
PRACTICAL COURSES AND TEACHING EXPERIENCE
Born 1964
in Bad Reichenhall, Bavarian Alpes, Germany
Citizenship
German
Marrital Status
Single
Primary School 1970-74 Grundschule Neustadt
and Böbingen (Pfalz)
High School 1974-83 Humanistic
Kurfürst-Ruprecht Gymnasium Neustadt (Weinstr.)
Protection against cathastrophes
(Molecular-
Screening of genomic libraries
Cell-Biology)
Institute of Cell and Tumor Biology
German Cancer Research Center Heidelberg
(Prof. D. Werner)
Training
Induction of PNET's (brain tumors)
(Neurobiology/
p53 mutations in nervous system tumors
Molecular Genetics)
Institute of Neuropathology
Department of Pathology
University of Zürich, Switzerland
(Prof. P. Kleihues and Prof. O.D. Wiestler)
ES cell and K.O. technology
CD44 splice-variants in brain tumors
MAb blocking of spontaneous metastases
Analysis of transgenic mice
Institute of Genetics, University of Karlsruhe
and Nuclear Research Center, Germany
(Prof. P. Herrlich)
License to practice Medicine
Stipend from European Community,
Stipend from Germany for Harvard/MGH,
then transferred to Stanford
Training
Rapid arrest of melanoma cells under flow
(Metastasis Research/
(VCAM-1/alpha-4 integrin)
Immunology)
CD44-hyaluronate mediate monocyte rolling
Chemokines, NOD-autoimmune model
Stanford University School of Medicine
Department of Pathology (Immunology)
(Prof. Irving L. Weissman / and Butcher-Lab)
---please ask directly for updated CV 4/2002---(eibl@mpip-mainz.mpg.de)
Cell Adhesion Receptors, Gene Therapy,
Neural-/hematopoetic Stem cells
Other Interests
People, California, Windsurfing, Internet,
Start-ups, Botanics, Entomology, Squash,
Photography, Diving, Sailing
1982 Honor Thesis in Biology (Gymnasium/High School)
"Variations and correlations of organs in Ranunculus ficaria"
(Plant Population Genetics and Ecology)
1984 - 85 Molecular Endocrinology, Institue of Biochemistry, University of Heidelberg
(Prof. W.E. Merz)
1984 - 85 Teaching Assistant at the Histology Course
Institute of Anatomy, University of Heidelberg
(Prof. Dariush Fahimi)
spring 1985 Guest Student at the Department of Surgery, Hospital at Montpellier, France
(Prof. Pierre Carabalona)
1985 — 86 Study of Mathematics (first year, parallel to medicine), University of Hagen
1985, 1986, 1987, 1988 Summer Exchange Student, University Montpellier, France
Sept. 1992 Course on Gene Targeting in Embryonic Stem Cells
(Max-Planck-Institute for Immunobiology
Department of Molecular Immunology, Freiburg
(Nobel-Laureate Prof. George Köhler)
1993 Course for Group Leaders on Bio-Safety/Bio-Hazard
German Cancer Research Center
1997-99 Stanford practical courses in Medical Teaching, Molecular Biology, Medical Ethics,
Multimedia, Video, WWW, Bio/Radio-Safety, Internet-Library ...
AWARDS, STIPENDS
1981 Botanic Excursion, Gerardmer, France (school award)
1982 Exchange student, Sommieres, southern France (school award)
1983 Visiting student, Avignon, Montpellier, Perpignan, southern France (county award)
1985 University of Montpellier, Medical Faculty and Maison de Heidelberg, France: Medical Training and financial support
1986 University of Heidelberg: Summer exchange student at University of Montpellier, France
1991 USZ, University of Zurich, Department of Pathology: Travel award for USA meetings (Frederick, San Diego, Boston)
1991 KFK, Nuclear Research Center Karlsruhe, Germany, Junior scientist fellowship
1992 MPI, Max-Planck-Institute, Immunobiology, Freiburg, Germany, Course and meeting on gene targeting
1992 EMBO, European Molecular Biology Organization, International workshop on leukocyte homing, Basel, Switzerland
1995 EEC, European Economic Community, Bruxelles, Human Capital and Mobility Stipend
1996 DFG, Deutsche Forschungsgemeinschaft, Bonn, Germany, Research Fellowship for Harvard and Stanford Universities
1999 Stanford University, School of Medicine, Dean's Fellowship
MEETINGS
May 1991 Zülch symposium: Growth control and neoplastic transformation
in the brain, Goslar, Germany (POSTER)
(Assistant of the Organizers: O.D. Wiestler, P. Kleihues, B. Seizinger)
June 1991 Seventh annual meeting on Oncogenes, Frederick, Maryland, USA (POSTER)
Sept.1991 36th annual meeting of the german society of Neuropathology and
Neuroanatomy, Düsseldorf, Germany (TALK)
Oct. 1991 Neurobiology Regio Meeting, Zürich, Switzerland (POSTER)
Nov. 1991 Annual meeting of the german society of Pathology, Bern
Switzerland (TALK)
June 1992 76th meeting of the german society of Pathology, Graz, Austria
(TALK)
Oct. 1992 5th Regio Meeting on gene targeting in embryonic stem cells
Max-Planck-Institue for Immunobiology, Freiburg, Germany
(Organizer: Nobel Laureate G. Köhler)
Nov. 1992 EMBO-workshop on cell-cell interactions in leukocyte homing
and differentiation, Basel Institute of Immunology, Basel,
Switzerland (ABSTRACT)
Feb. 1993 1st workshop on adhesion molecules, german society of
Immunology, German Cancer Research Center, Heidelberg (TALK)
Nov. 1993 Gene diagnosis and gene therapy, German Cancer Research
Center, Heidelberg
July 1994 J.P. Lecocq conference on gene therapy, (Organizer: P. Chambon)
Strasbourg, France (POSTER)
Sept. 1994 Annual meeting of the german society of Neuropathology and
Neuroanatomy, Munich, Germany
1995+6 EMBO-Meetings, EMBL Heidelberg, Germany
Oct. 1997 Asilomar-Meeting, Stanford Immunology, USA (POSTER)
April 1998 FASEB meeting: Experimental Biology, San Francisco, USA
1998 Different molecular biology/immunology conferences at Stanford
April 1999 1st Gene therapy meeting at Stanford University
Mai 1999 Meeting: celebration of 10 years of Beckman Center
July 1999 Western Conference in Immunology 1999, Stanford, USA,
CD44 mediates rolling of monocytes (_20 min TALK_)
Oct. 1999 International Symposium of the Collaborative
Neuroscience Research Center Bonn, Germany
CD44 splice-variants with v3 and v6 exon sequences
are frequently expressed in astrocytic brain tumors
(accepted for Poster)
2000 prizes for Business plan and Nomination; 2001 Nomination for prize; 2002 DFG Bonn, Germany awards 1500 $ for travel money to the USA
PUBLICATION LIST
(July 1999)Science Citation Index (statistics):
Total
Citations: >>500 update 7/99First Author Citations: 31 (Two publications)
1.
Preuss I, Haas S, Eichhorn U, Eberhagen I, Kaufmann M, Beck T, Eibl RH, Dall P, Bauknecht T, Hengstler J, Wittig BM, Dippold W, Kaina B
Activity of the DNA repair protein O6-methylguanine-DNA methyltransferase in human tumor and corresponding normal tissue.
Cancer Detection and Prevention 1996;20(2):130-136
(Citations in Science Citation Index: 6)
2.
Eibl RH, Pietsch T, Moll J, Skroch-Angel P, Heider KH, von Ammon K, Wiestler OD, Ponta H, Kleihues P, Herrlich P
Expression of variant CD44 epitopes in human astrocytic brain tumors.
Journal of Neuro-Oncology 1995 Dec;26(3):165-170
(Citations in Science Citation Index: 18)
3.
Preuss I, Eberhagen I, Haas S, Eibl RH, Kaufmann M, von Minckwitz G, Kaina B
O6-methylguanine-DNA methyltransferase activity in breast and brain tumors.
International Journal of Cancer 1995 May 4;61(3):321-326
(Citations in Science Citation Index: 19)
4.
Eibl RH, Kleihues P, Jat PS, Wiestler OD
A model for primitive neuroectodermal tumors in transgenic neural transplants harboring the SV40 large T antigen.
American Journal of Pathology 1994 Mar;144(3):556-564
(Citations in Science Citation Index: 13,
also cited in international Textbook of Neurosurgery and Newspapers)
5.
Wiestler OD, Brustle O, Eibl RH, Radner H, Aguzzi A, Kleihues P
Oncogene transfer into the brain.
Recent Results in Cancer Research 1994;135:55-66
(Citations in Science Citation Index: 4)
6.
Kleihues P, Ohgaki H, Eibl RH, Reichel MB, Mariani L, Gehring, M, Petersen I, Holl T, von Deimling A, Wiestler OD, Schwab M
Type and frequency of p53 mutations in tumors of the nervous system and its coverings.
Recent Results in Cancer Research 1994;135:25-31
(Citations in Science Citation Index: 5)
7.
Ohgaki H, Eibl RH, Schwab M, Reichel MB, Mariani L, Gehring, M, Petersen I, Holl T, Wiestler OD, Kleihues P
Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system.
Molecular Carcinogenesis 1993;8(2):74-80
(Citations in Science Citation Index: 77)
8.
Louis DN, von Deimling A, Chung RY, Rubio MP, Whaley JM, Eibl RH, Ohgaki H, Wiestler OD, Thor AD, Seizinger BR
Comparative study of p53 gene and protein alterations in human astrocytic tumors.
Journal of Neuropathology & Experimental Neurology 1993
Jan;52(1):31-38
(Citations in Science Citation Index: 129)
9.
Radner H, el-Shabrawi Y, Eibl RH, Brustle O, Kenner L, Kleihues P, Wiestler OD
Tumor induction by ras and myc oncogenes in fetal and neonatal brain: modulating effects of developmental stage and retroviral dose.
Acta Neuropathologica (Berl) 1993;86(5):456-465
(Citations in Science Citation Index: 4)
10.
Wiestler OD, Brustle O, Eibl RH, Radner H, Von Deimling A, Plate K, Aguzzi A, Kleihues P
A new approach to the molecular basis of neoplastic transformation in the brain.
Neuropathology and Applied Neurobiology 1992 Oct;18(5):443- 453
(Citations in Science Citation Index: 6)
11.
Wiestler OD, Aguzzi A, Schneemann M, Eibl R, von Deimling A, Kleihues P
Oncogene complementation in fetal brain transplants.
Cancer Research 1992 Jul 1;52(13):3760-3767
(Citations in Science Citation Index: 17)
12.
von Deimling A, Eibl RH, Ohgaki H, Louis DN, von Ammon K, Petersen I, Kleihues P, Chung RY, Wiestler OD, Seizinger BR
p53 mutations are associated with 17p allelic loss in grade II and grade III astrocytoma.
Cancer Research 1992 May 15;52(10):2987-2990
(Citations in Science Citation Index: 176)
13.
Wiestler OD, Brustle O, Eibl RH, Radner H, Aguzzi A, Kleihues P
Retrovirus-mediated oncogene transfer into neural transplants.
Brain Pathology 1992 Jan;2(1):47-59
(Citations in Science Citation Index: 19)
14.
Ohgaki H, Eibl RH, Wiestler OD, Yasargil MG, Newcomb EW, Kleihues P
p53 mutations in nonastrocytic human brain tumors.
Cancer Research 1991 Nov 15;51(22):6202-6205
(Citations in Science Citation Index: 124)
Paper in preparation:
Eibl RH, Gosslar U, (Abstract submitted for presubmission request)
alpha 4 integrin and its endothelial ligand VCAM-1 mediate rapid and firm arrest of metastasizing melanoma cells under conditions of flow
Hubbe M, Eibl RH (Meeting-Abstract published)
CD44-hyaluronate binding mediates rolling of monocytes
Eibl RH, et al. (Meeting-Abstract published in a biomedical Journal )
Frequent expression of specific CD44 variants in astrocytomas and glioblastomas
References:
Prof. Dr. rer. nat. Wolfgang Knoll
Director Max Planck Institute
Ackermannweg 10
D-55128 Mainz
GERMANY
Irving L. Weissman, M.D.
Professor
Department of Pathology
Stanford University
Stanford, CA 94305-5323
U S A
e-mail: irv@stanford.edu