| Year | Event |
| 1945 | The United Nations are founded on Earth.
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| 1957 | Earth's space age begins with the launch of the first artificial satellite, Sputnik 1. |
| 1992 | Khan Noonien Singh, product of late 20th century experiments with genetic engineering, rises to power, assuming control over one quarter of planet Earth |
| 1993 | A group of genetically engineered "superior" humans seize power simultaneously in some forty of Earth's nations, mainly in the so-called "third world". The terrible Eugenic wars ensue, in part because the genetic "supermen" take to fighting among themselves. Entire populations are bombed out of existence. |
| 1996 | The Eugenic Wars end. Khan Noonien Singh is overthrown and escapes from Earth in the DY-100 class sleeper ship SS Botany Bay along with 96 of his fellow genetic "supermen". |
| 2009 | Shaun Geoffry Christopher commands the first manned Earth-Saturn space-probe mission |
| 2024 | An uprise in San Fancisco's Sanctuary District A leads to the abolishment of these inhuman institutions, originally established to accomodate homeless and jobless people. This event, later known as the "Bell riots", makes the people start to face the serious social problems it has struggled with for over a century. |
| 2053 | World War III, a nuclear conflict on planet Earth, ends after more than 37 millions of people were killed. |
| 2061 | Warp drive is invented by Zefram Cochrane. |
| 2063 | Humans establish first contact with an alien race when a Vulcan scout ship discovers the warp signature of Zefram Cochrane's ship, the Phoenix. |
| 2065 | SS Valiant is lost on an exploration mission into deep space. |
| 2079 | The Age of postatomic horror: Earth begins to recover from World War III. |
| 2117 | Zefram Cochrane, now residing in the Alpha Centauri system, disappears and is believed to be dead. |
| 2150 | The first real world government is established on planet Earth with the state of Australia joining the union. |
| 2156 | War breaks out between Earth and the Romulan Star Empire. It is fought with primitive nuclear weapons, and the Romulan ships are not even equipped with warp drive. |
| 2160 | The Romulan war ends in the battle of Charon, with Earth Forces eventually defeating the Romulan fleet. The Treaty of Algeron is negotiated over subspace radio, creating a 1 Light-year wide "Neutral Zone" between Earth and Romulan space. |
| 2161 | The United Federation of Planets is founded. Starfleet is established in the same year with a charter "to boldy go where no man has gone before".
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| 2218 | First contact with the Klingon Empire. This disastrous encounter leads to almost a whole century of hostilities between the Empire and the Federation. |
| 2243 | Dr. Richard Daystrom invents duotronic computer technology which becomes basis for the main computers used aboard the starship Enterprise. |
| 2245 | The USS Enterprise NCC-1701 is launched from the San Francisco Yards. Captain Robert April assumes command of the Constitution-class ship and begins a five-year mission of exploration. |
| 2250 | James T. Kirk enrolls in Starfleet Academy. First assignment is USS Republic NCC-1371. |
| 2251 | Christopher Pike assumes command of USS Enterprise to command its second five-year mission to explore deep space. |
| 2252 | Spock, still an Academy cadet, begins service aboard USS Enterprise. |
| 2253 | Spock graduates from Academy. Dr. Leonard McCoy graduates from medical school. |
| 2254 | James Kirk graduates from Starfleet Academy. He is the only cadet ever to beat the "no-win scenario" of the Kobayashi-Maru simulation. He is assigned duty aboard USS Farragut. |
| 2255 | United Federation of Planets and Sheliak corporate sign Treaty of Armens. |
| 2256 | The USS Enterprise completes its second five-year mission of exploration and begins a year of refit work in spacedock. |
| 2257 | Enterprise embarks on third five-year mission. |
| 2261 | USS Enterprise, under the command of Christopher Pike, completes its third five-year mission of exploration. The ship enters spacedock for a major refit. |
| 2263 | James Kirk is promoted to captain of the starship Enterprise. |
| 2264 | The Enterprise under Kirk embarks on a historic five-year mission of exploration. |
| 2266 | The Romulans violate the Neutral Zone for the first time in more than a hundred years.
Captain Pike returns to planet Talos IV to spent the rest of his life there. |
| 2267 | Khan's sleeper ship, the SS Botany Bay, is found drifting in Mutara sector. Khan and his fellows are banished to planet Ceti Alpha VI.
Relations between Federation and Klingon Empire start to deteriorate; war is prevented by the Organian peace treaty. |
| 2268 | Establishment of Klingon-Romulan alliance, which permits an exchange of starship design and waepon technology between the two empires, icluding the cloaking device (invented by Romulans).
Captain James Kirk and Commander Spock are arrested by Romulan authorities on a mission to seize an improved Romulan cloaking device. |
| 2269 | Kirk's five-year mission aboard the Enterprise comes to an end. The ship returns to spacedock to undergo a major refit. Kirk is promoted to Admiral, Spock and McCoy leave Starfleet. |
| 2271 | The Enterprise successfully defends Earth against the V'Ger space probe. Spock and McCoy re-enter Starfleet. |
| 2284 | Spock becomes instructor at Starfleet Academy. The USS Enterprise is assigned to Academy training flights. |
| 2285 | Khan Noonien Singh escapes exile on Ceti Alpha VI, gains control of USS Reliant and tries to steal the Genesis terraforming device.
Spock dies in trying to save the Enterprise.
While Kirk and his Crew are trying to save Spock's body, the Enterprise is destroyed. Later on, Spock's body, re-born on planet Genesis, is reunited with his Katra (his mind).
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| 2286 | Kirk and companions save Earth from an alien probe by transporting two humpback whales from the 20th to the 23rd century.
The USS Enterprise NCC-1701-A, second ship to bear the name, is commissioned. Admiral Kirk is demoted to Captain and assumes command of the new starship. |
| 2287 | Sybok, Spock's half brother, gains control of the Enterprise trying to find his vision of god which is believed to live on planet Sha Ka Ree. |
| 2290 | Hikaru Sulu is promoted captain of USS Excelsior NCC-2000. |