Mikhail A. Lebedev
Senior Research Scientist
Center
for Neuroengineering
Department of Neurobiology
Duke
University
Medical
Center
Box
3209
101
Research Drive
Durham,
NC 27710
Telephone: (919) 668 1236
Fax: (919) 681 7055
E-mail: lebedev at neuro dot duke dot edu
RESEARCH
Representation of peripheral stimuli in the primary somatosensory cortex. In this study conducted at
laboratory of Dr. Randall Nelson at the University of Tennessee, Memphis, I analyzed the representation of
temporal patterns of peripheral somatosensory stimuli
in the primary somatosensory cortex (S1) of awake,
behaving monkeys. Monkeys responded to vibrotactile
stimulation of their palms with movements of their hands (wrist flexions and
extensions). It was found that many S1 neurons are entrained (or
phase-locked) to peripheral vibration. Moreover, entrainment patterns
change during motor preparation, indicating premovement
corollary discharges coming to S1 from motor areas of the brain.
References
Lebedev, M.A., Denton, J.M., Nelson,
R.J. (1994) Vibration-entrained and premovement
activity in monkey primary somatosensory cortex. J. Neurophysiol.
72: 1654-1673.
Lebedev, M.A.,
Nelson, R.J. (1996) High-frequency vibratory sensitive neurons in monkey
primary somatosensory cortex: entrained and
non-entrained responses to vibration during the performance of vibratory-cued
hand movements. Exp. Brain Res. 111: 313-325.
Oscillatory
patterns in cortical neurons. In this series of studies conducted with Dr. Randall J.
Nelson I examined oscillatory patterns of activity in single neurons recorded
in the cortex and basal ganglia of awake, behaving monkeys. Oscillatory
neurons exhibited specific modulations of their activity during the execution
of motor tasks. Moreover, single-neuron oscillations were found to be
directionally specific.
References
Lebedev,
M.A., Wise, S.P. (2000) Oscillations in the premotor
cortex: single-unit activity from awake, behaving monkeys. Exp. Brain
Res., 130: 195-215.
Lebedev,
M.A., Nelson, R.J. (1999) Rhythmically firing neostriatal neurons in monkeys: activity patterns during
reaction-time hand movements. J. Neurophysiol.,
82: 1832-1842.
Lebedev,
M.A., Nelson, R.J. (1995) Rhythmically firing (20-50
Hz) neurons in monkey primary somatosensory cortex:
activity patterns during initiation of vibratory-cued hand movements. J. Comput. Neurosci. 2: 313-334.
Plasticity
and information encoding in rat barrel cortex. In this study conducted at the
laboratory of Dr. Mathew Diamond at SISSA, Trieste, Italy, multielectrode
recordings in rat barrel cortex were used to uncover plasticity of sensory
responses evoked by the changes in behavioral use of peripheral somatosensory inputs (whisker pairing). In addition,
information-theoretic analysis of sensory representations in rat barrel cortex
was performed.
References
Panzeri,
S., Petersen, R.S., Schultz, S.R., Lebedev, M.A.,
Diamond, M.E. (2001) The role of spike timing in the
coding of stimulus location in rat somatosensory
cortex. Neuron, 29: 769-777.
Panzeri, S., Peterrsen,
R.S., Schultz, S.R., Lebedev, M.A., Diamond, M.E.
(2001) Coding of stimulus location by spike timing in rat somatosensory
cortex. Neurocomputing, 44: 573-578.
Mitz, A.R., Boring, S.A., Wise, S.P., Lebedev, M.A. (2001) A novel food-delivery device for neurophysiological and neuropsychological studies in
monkeys. J.
Neurosci. Methods, 109: 129-135.
Lebedev,
M.A., Mirabella, G., Erchova, I., Diamond, M.E. (2000)
Experience-dependent plasticity of rat barrel cortex: redistribution of
activity across barrel-columns. Cerebral Cortex, 10: 23-31.
Representation of multiple spatial variables in monkey
frontal cortex. In this series of studies conducted
at the laboratory of Steven Wise at NIMH, Bethesda, Maryland, I analyzed activity patterns of
frontal cortex neurons that encode a variety of spatial parameters: orientation
of selective spatial attention, target of reach, gaze angle, spatial memory.
Behavioral tasks were specifically designed in such way that these variables
were controlled independently. A number of findings illuminating spatial
encoding in the frontal cortex came from these studies. For example, it
was found that many premotor cortex neurons represent
orientation of spatial attention rather than motor preparation. In
addition, it was shown that the majority prefrontal activity patterns commonly
described as representing spatial working memory are related to the orientation
of spatial attention.
References
Lebedev,
M.A., Messinger, A., Kralik,
J.D., Wise, S.P. (2004) Representation of attended versus remembered locations
in prefrontal cortex. PLoS Biology, 2:
1919-1935.
Lebedev,
M.A., Wise, S.P. (2002) Insights into seeing and grasping: distinguishing the
neural correlates of perception and action. Behavioral and Cognitive
Neuroscience Reviews, 1: 108-129.
Lebedev, M.A., Wise, S.P. (2001) Tuning for
the orientation of spatial attention in dorsal premotor
cortex. Eur. J. Neurosci.,
13: 1002-1008.
Lebedev,
M.A., Douglass, D.K., Moody, S.L., Wise, S.P. (2001) Prefrontal cortex neurons
reflecting reports of a visual illusion. J. Neurophysiol.,
85: 1395-1411.
Brain-machine
interfaces. My
current work as a Senior Research Scientist at Miguel Nicolelis lab is a part
of the effort of Duke University consortium to build prosthetic
devices for restoration of motor control in neurologically disabled people.
This ambitious goal can only be accomplished though collaboration of experts
from many fields: biomedical engineers, clinicians, neurophysiologists. Being a
member of this multidisciplinary team, I was involved in the development of a
brain-machine interface for reaching and grasping, the study of representation
of time by cortical neuronal ensembles, the studies of cortical representation
of locomotion patterns in monkeys and rats, an investigation of predictions of
EMG patterns from neuronal ensemble activity and a microstimulation
study that explored the ways to sensorize neural prosthetic
devices.
References
Lebedev,
M.A., Nicolelis, M.A.L. (2005) Brain-machine interfaces: past, present and
future. Trends in Neurosci., 29: 493-546..
Lebedev, M.A., Carmena, J.M., O’Doherty, J.E., Zacksenhouse,
M., Henriquez, C.S., Principe,
J.C., Nicolelis, M.A.L. (2005) Cortical ensemble adaptation to represent
actuators controlled by a brain machine interface. J. Neurosci., 25: 4681-4693.
Santucci,
D.M., Kralik, J.D., Lebedev , M.A., Nicolelis,
M.A.L. (2005) Frontal and parietal cortical ensembles predict single-trial
muscle activity during reaching movements Eur.
J. Neurosci., 22: 1529-1540.
Kim, H.K.,
Biggs, S.J., Schloerb, D.W., Carmena,
J.M., Lebedev, M.A., Nicolelis, M.A.L., Srinivasan, M.A. (2005). Continuous shared control
stabilizes reach and grasping with brain-machine interfaces. IEEE
Trans. on Biomed. Eng., in press.
Carmena,
J.M., Lebedev, M.A., Henriquez,
C.S., Nicolelis, M.A.L. (2005) Stable ensemble performance with single neuron
variability during reaching movements in primates. J. Neurosci., in press.
Sanchez,
J.C., Carmena, J.M., Lebedev,
M.A., Nicolelis, M.A., Harris, J.G., Principe, J.C. (2004) Ascertaining the importance of neurons
to develop better brain machine interfaces. IEEE Trans Biomed
Eng., 51: 943-953.
Carmena,
J.M., Lebedev, M.A., Crist,
R.E., O’Doherty, J.E., Santucci,
D.M., Dimitrov, D.F., Patil,
P.G., Henriquez, C.S., Nicolelis, M.A.L. (2003)
Learning to control a brain-machine interface for reaching and grasping by
primates. PLoS Biology, 1:
193-208.
APPOINTMENTS
2002-present
|
Senior
Research Scientist
|
Center
for Neuroengineering, Department of Neuroscience, Duke University, NC
|
1997-2002
|
Research
Fellow
|
Laboratory
of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD
|
1995-1997
|
Postdoctoral
Fellow
|
Cognitive
Neuroscience Sector, International School for Advanced Studies, Trieste, Italy
|
1995
|
Postdoctoral
Fellow
|
Department
of Anatomy and Neurobiology, University of Tennessee, Memphis, TN
|
1991-1995
|
Graduate
Teaching Assistant
|
Department
of Anatomy and Neurobiology, University of Tennessee, Memphis, TN
|
1986-1991
|
Research
Fellow
|
Institute
for the Problems of Information Transmission, Moscow, Russia
|
SOCIETY
MEMBERSHIP
1992 -
present
|
Society
for Neuroscience
|
2005 -
present
|
Cognitive
Neuroscience Society
|
INVITED
LECTURES
2007,
June
|
Decoding and encoding with multielectrode
implants
|
Neurizons. Max Planck Institute for Experimental Medicine, Göttingen, Germany
|
2007,
April
|
Decoding multiple behavioral variables from neuronal ensemble activity
|
Advanced
Telecommunications Research Institute International, Kyoto, Japan
|
2006,
April
|
Encoding of attended
versus remembered locations by prefrontal cortex neurons
|
Cognitive Neuroscience Meeting, San Francisco, California
|
2006,
February
|
Obtaining accurate
read-out of multiple behavioral variables from large neuronal ensembles
|
Barrow Neurological Institute, Phoenix, Arizona
|
2004,
August
|
Frontal cortex mechanisms of spatial motor behavior
|
IBRO Summer School: Sensory and
Integrative Neuroscience, Moscow, Russia
|
2003,
December
|
Monkey attend, monkey do. Dissociation of spatial
attention from other variables in task-related activity of frontal cortex
neurons
|
Department of Neurobiology and
Anatomy, Wake Forest University, North Carolina
|
2002, May
|
Processing of spatial information in frontal cortex
|
Department of Neurobiology, Duke University, North Carolina
|
2002,
April
|
Dissociation of spatial, mnemonic, attentional,
and intentional signals related to reaching movements and eye movements in
frontal cortex.
|
Neural Control of Movement
Meeting, Naples, Florida
|
2002,
February
|
Processing
of spatial information in frontal cortex
|
Department of Psychology, Vanderbilt University, Nashville, TN
|
2000,
July
|
Oscillations
in the activity of individual premotor cortex
neurons
|
Department of Psychology, Vanderbilt University, Nashville, TN
|
1998,
December
|
Premotor cortex: detection of oscillations in single-unit activity
|
Human Motor Control Section,
National Institute of Neurological Disorders and Stroke
|
1998, May
|
Single unit oscillations in SI
during reaction-time movements
|
Second Borsellino College of Neurophysics.
The Abdus Salam
International Centre for Theoretical Physics
|
1995,
February
|
Rhythmic
activity of SI neurons
|
Cognitive Neuroscience Sector, International School for Advanced Studies, Trieste, Italy
|
INVITED
REVIEWER
Journal of Neurophysiology
European Journal of Neuroscience
Experimental Brain Research
Neural Computation
IEEE Transactions on Biomedical Engineering
International Journal of Psychophysiology
PUBLICATIONS
- Zacksenhouse, M.,
Lebedev, M.A., Carmena,
J.M., O’Doherty, J.E., Henriquez,
C.S., Nicolelis, M.A.L. Cortical Modulations Increase in Early Sessions
with Brain-Machine Interface. PlosOne (in press).
- Fitzsimmons, N.A., Drake, W., Hanson, T.L., Lebedev, M.A., Nicolelis, M.A.L. (2007)
Primate Reaching Cued by Multichannel
Spatiotemporal Cortical Microstimulation. J. Neurosci.,
27: 5593-5602.
- Lebedev, M.A., Nicolelis, M.A.L. (2006)
Brain-machine interfaces: past, present and future. Trends in Neurosci., 29: 493-546.
- Kim,
S..P, Sanchez, J.C., Rao,
Y.N., Erdogmus, D., Carmena,
J.M., Lebedev, M.A., Nicolelis,
M.A.L., Principe, J.,C.
(2006) A comparison of optimal MIMO linear and nonlinear models for
brain-machine interfaces. J Neural Eng., 3: 145-161.
- Kim,
H.K., Biggs, S.J., Schloerb, D.W., Carmena, J.M., Lebedev,
M.A., Nicolelis, M.A.L., Srinivasan, M.A.
(2006). Continuous shared control stabilizes reach and grasping with
brain-machine interfaces. IEEE Trans. on Biomed.
Eng., 53(6): 1164-1173.
- Lebedev, M.A., Carmena,
J.M., O’Doherty, J.E., Zacksenhouse,
M., Henriquez, C.S., Principe, J.C., Nicolelis, M.A.L.
(2005) Cortical ensemble adaptation to represent actuators controlled by a
brain machine interface. J. Neurosci., 25: 4681-4693.
- Santucci, D.M., Kralik, J.D., Lebedev , M.A., Nicolelis, M.A.L. (2005) Frontal
and parietal cortical ensembles predict single-trial muscle activity
during reaching movements Eur. J. Neurosci., 22: 1529-1540.
- Carmena, J.M., Lebedev, M.A., Henriquez, C.S., Nicolelis, M.A.L. (2005) Stable ensemble
performance with single neuron variability during reaching movements in
primates. J. Neurosci., in press.
- Lebedev, M.A., Messinger, A., Kralik, J.D., Wise, S.P. (2004) Representation of
attended versus remembered locations in prefrontal cortex. PLoS Biology, 2: 1919-1935.
- Sanchez,
J.C., Carmena, J.M., Lebedev,
M.A., Nicolelis, M.A., Harris, J.G., Principe, J.C. (2004) Ascertaining the
importance of neurons to develop better brain machine interfaces. IEEE
Trans Biomed Eng., 51: 943-953.
- Carmena, J.M., Lebedev,
M.A., Crist, R.E., O’Doherty,
J.E., Santucci, D.M., Dimitrov,
D.F., Patil, P.G., Henriquez,
C.S., Nicolelis, M.A.L. (2003) Learning to control a brain-machine
interface for reaching and grasping by primates. PLoS
Biology, 1: 193-208.
- Lebedev, M.A., Wise, S.P. (2002) Insights into seeing and grasping:
distinguishing the neural correlates of perception and action. Behavioral
and Cognitive Neuroscience Reviews, 1: 108-129.
- Erchova, I., Lebedev, M.A.,
Diamond, M.E. (2002) Somatosensory
cortical neuronal population activity across states of anesthesia. Eur. J. Neurosci.,
15: 744-752.
- Lebedev, M.A., Wise, S.P. (2001) Tuning for the orientation of
spatial attention in dorsal premotor
cortex. Eur. J. Neurosci., 13: 1002-1008.
- Lebedev, M.A., Douglass, D.K., Moody, S.L., Wise, S.P. (2001)
Prefrontal cortex neurons reflecting reports of a visual illusion. J. Neurophysiol., 85: 1395-1411.
- Nelson,
R.J., Lebedev, M.A. (2001)
Deciphering the code - dynamic modulation of neural activity during
tactile behavior - chapter 10. In: Nelson R.J. (Ed.) Somatosensory System: Deciphering the
Brain's Own Body Image, CRC Press.
- Panzeri, S., Petersen, R.S., Schultz, S.R., Lebedev, M.A., Diamond, M.E. (2001) The role of spike timing in the coding of stimulus
location in rat somatosensory cortex. Neuron,
29: 769-777.
- Panzeri, S., Peterrsen, R.S.,
Schultz, S.R., Lebedev, M.A.,
Diamond, M.E. (2001) Coding of stimulus location by spike timing in rat somatosensory cortex. Neurocomputing,
44: 573-578.
- Mitz, A.R., Boring, S.A., Wise, S.P., Lebedev, M.A. (2001) A novel
food-delivery device for neurophysiological and
neuropsychological studies in monkeys. J. Neurosci.
Methods, 109: 129-135.
- Lebedev, M.A., Mirabella, G., Erchova, I., Diamond, M.E. (2000)
Experience-dependent plasticity of rat barrel cortex: redistribution of
activity across barrel-columns. Cerebral Cortex, 10: 23-31.
- Lebedev, M.A., Wise, S.P. (2000) Oscillations in the premotor cortex: single-unit activity from awake,
behaving monkeys. Exp. Brain Res., 130: 195-215.
- Lebedev, M.A., Nelson, R.J. (1999) Rhythmically
firing neostriatal neurons in monkeys: activity
patterns during reaction-time hand movements. J. Neurophysiol.,
82: 1832-1842.
- Mirabella,
G., Lebedev, M.A., Diamond, M.E.
(1999) Integration and storage of sensory events in adult rat barrel
cortex. In: M. Kossut (Ed.) Plasticity of
Adult Rat Barrel Cortex, F.P. Graham, Johnson City, TN: 97-126.
- Lebedev, M.A., Nelson, R.J. (1996) High-frequency vibratory
sensitive neurons in monkey primary somatosensory
cortex: entrained and non-entrained responses to vibration during the
performance of vibratory-cued hand movements. Exp. Brain Res. 111:
313-325.
- Lebedev, M.A., Nelson, R.J. (1995) Rhythmically
firing (20-50 Hz) neurons in monkey primary somatosensory
cortex: activity patterns during initiation of vibratory-cued hand
movements. J. Comput. Neurosci.
2: 313-334.
- Lebedev, M.A., Denton, J.M., Nelson, R.J. (1994)
Vibration-entrained and premovement activity in
monkey primary somatosensory cortex. J. Neurophysiol. 72: 1654-1673.
- Lebedev, M.A. (1993) Further observations
on ischemic suppression of motor units in human soleus
muscle. A single case study. J. Electromyography and Kinesiology 3:
183-186.
- Gurfinkel, V.S., Lebedev,
M.A., Levick, Yu.S.
(1992) What about the so-called neck reflexes in
humans? In: A. Bertoz, W. Graf, P. P. Vidal (Eds) The Head-Neck
Sensory Motor System, New York, Oxford, Oxford University Press: 543-547.
- Gurfinkel, V.S., Lebedev,
M.A., Levik, Yu.S.
(1992) Effects of reversal in the human equilibrium regulation system. Neirofiziologiya (Kiev) 24: 462-470.
Translation into English: Neurophysiology 24: 297-304.
- Gurfinkel, V.S., Lebedev,
M.A., Levik, Yu.S.
(1992) The sensory effects caused by neck afferentation. Sensory Systems 6: 83-87.
- Lebedev, M.A., Polyakov, A.V. (1992)
Analysis of surface EMG of human soleus muscle
subjected to vibration. J. Electromyography and Kinesiology 2:
26-35.
- Gurfinkel, V.S., Levick, Yu.S. Lebedev,
M.A. (1991) Body scheme concept and motor control. Body scheme in the
postural automatisms regulation. In: Intellectual Processes and Their Modelling, Moscow, Nauka:
24-53.
- Lebedev, M.A. (1991) Impairment of human soleus
motor units during ischemia. J. Electromyography and Kinesiology 1:
244-249.
- Lebedev, M.A., Polyakov, A.V. (1991)
Analysis of the interference electromyogram of
the human soleus muscle under vibrational stimulation. Neirofiziologiya
(Kiev) 23: 57-65. Translation into
English: Neurophysiology 23: 47-54.
- Lebedev, M.A., Polyakov, A.V. (1990) The analysis of surface EMG of human soleus muscle during vibration. In: Systems of
Information Transmission and Processing. Institute for the Problems of
Information Transmission, USSR Acad. Sci,
Moscow: 34-38.
- Gurfinkel, V.S., Levik, Yu.S.,
Lebedev, M.A. (1989) Immediate and
remote postactivation effects in the human motor
system. Neirofiziologiya (Kiev) 21: 343-351. Translation into
English: Neurophysiology 21: 247-253.
- Gurfinkel, V.S., Levik, Yu.S.,
Lebedev, M.A. (1989) The postural
automatism revealed by the enhancement of tonic background. Postural
automatisms revealed by tonic background activation. Doklady
Akademii Nauk SSSR
305:1266-1269.
- Lebedev M.A., Polyakov A.V. (1989)
Switched vibratory activation of muscle. 1. Spectral analysis of surface
EMG. In: Systems of Information Transmission and Processing.
Institute for the Problems of Information Transmission USSR Acad. Sci,
Moscow: 54-58.
- Polyakov, A.V., Lebedev,
M.A. (1989) Switched vibratory activation of muscle. 2. Motor
unit firing. In: Systems of Information Transmission and Processing.
Institute for the Problems of Information Transmission, USSR Acad. Sci,
Moscow: 59-61.
- Lebedev, M.A. (1988) Domination of peripheral visual field in human
vertical posture control. In: Systems of
Information Transmission and Processing. Part 1. Institute for the
Problems of Information Transmission, USSR Acad. Sci,
Moscow: 61-63.
- Lebedev, M.A. (1988) Research methods of basic postural control
mechanisms. In: Systems of Information Transmission and
Processing. Part 2. Institute for the Problems of Information
Transmission, USSR Acad. Sci,
Moscow: 64-67.