Cytokines
- products of activated lymphocytes and macrophages
- attract inflammatory cells
- stimulate fibroblast proliferation, collagen synthesis
- Interleukin (IL), tumor necrosis factor (TNF)
- secreted by T lymphocytes and macrophages
- pyrogens (act on hypothalamus to induce fever)
- increase vascular permeability
- attract and activate neutrophils
- TNF causes release of proteolytic enzymes
- interferon - interferes with viral replication
- gets uninfected cells ready for viral attack