CURRICULUM VITAE

William S. Asch

Department of Biochemistry and Cell Biology

SUNY at Stony Brook

HSC T-10 Room 050

Stony Brook, NY 11794

(516)    444-3425 (Phone)

(517)    444-7534 (FAX)

Email: WmAsch@yahoo.com

EDUCATION:

INSTITUTION AND LOCATION                           DEGREE               YEAR CONFERRED             SCIENTIFIC FIELD

Brandeis University, Waltham MA                      B.A.                         1993                                         Biology

SUNY at Stony Brook, Stony Brook NY              Ph.D.                      2000 (expected)                     Molecular Biology

SUNY at Stony Brook School of Medicine         M.D.                        2001 (expected)                     Medicine

CAREER INTERESTS:

Academic career in cardiovascular medicine and clinical research

HONORS AND AWARDS:

Honors courses and clerkships: Medicine, Medicine Subinternship, Neurology, Psychiatry

Excellence in Graduate Research Award, 1997 Nominee

ASSOCIATIONS:

American Medical Association, Member

Society for Neuroscience, Member

MD/PhD Program Activities:

MD/PhD Symposium Co-Chairperson, 1996

MD/PhD Committee Student Representative, 1995-96.

RESEARCH EXPERIENCE:

Graduate Student, Department of Molecular and Cellular Biology, State University of New York at Stony Brook (6/1/95 to Present)

Undergraduate Research Assistant, Department of Biology, Brandeis University, Waltham MA (1/1/91 to 6/1/93)

SUMMARY OF RESEARCH INTERESTS:

1991 - 1993             Molecular Isolation and Characterization of the TATA Binding Protein (TBP) from Volvox Carteri for use as a tool in elucidating the molecular components necessary for cell type specific gene expression.

CURRENT RESEARCH:

A.            General Problem

Molecular neurobiology of visual pathway development using goldfish and zebrafish as model systems.

B.             Specific Problem

The role of intermediate filament proteins in nerve growth and regeneration.

Regulation of intermediate filament protein expression in developing zebrafish embryos.

Histological localization of intermediate filament proteins in the zebrafish visual pathway.

Molecular cloning of cDNAs and genes for intermediate filament proteins.

Regulation of intermediate filament protein expression in cell culture systems.

The effect of intermediate filament over and under expression in developing zebrafish embryos.

The effect of dominant negative intermediate filaments during zebrafish embryonic development.

GENBANK SUBMISSIONS:

Zebrafish Plasticin, a type III intermediate neurofilament protein, complete cds.

Accession Number U89709

Zebrafish Gefiltin, a type IV intermediate neurofilament protein, complete cds.

Accession Number U89710

Zebrafish Plasticin 3' Splice Variant, a type III intermediate neurofilament protein, complete cds.

Accession Number AF024598

Zebrafish Plasticin Promoter, partial genomic sequence.  Accession Number (Bankit#285430)

PUBLICATIONS:

Plasticin, a Type III Neuronal Intermediate Filament Protein, Asssembles as an Obligate Heteropolymer: Implications for Axonal Flexibility.  (In press, Summer 2000)  W. S. Asch and N. Schechter.  J. Neurochem.

Gefiltin expression in zebrafish embryos: sequential expression of two neurofilament proteins in retinal ganglion cells.  (1999)  Leake, D , Asch, W.S., Canger,  A.K., and Schechter, N.  Differentiation. 65:181-189.

Restricted Expression of the Neurofilament Protein Plasticin During Zebrafish Development. (1998)  A.K. Canger, M. Passini, W. S. Asch, D. Leake, B. T. Zafonte, E. Glasgow, and N. Schechter.  J. Comp. Neurol. 399:561-572.

Cloning of Zebrafish vsx1: Expression of a paired-Like homeobox Gene During CNS Development. (1998)  M. A. Passini, L. Kurtzman, A. K. Canger, W. S. Asch, G. A. Wray, P. A. Raymond, and N. Schechter.  Dev. Genetics. 23:128-141.

Cloning of the Zebrafish Neurofilament Proteins Plasticin and Gefiltin: Increased mRNA Expression in Retinal Ganglion Cells After Optic Nerve Crush. (1998) W.S. Asch, D. Leake, A.K. Canger, M. Passini, F. Argenton, and N. Schechter.  J. Neurochem. 71(1); 20-32.

ABSTRACTS:

Effects of EBS Mutations on Assembly of Zebrafish Plasticin and Gefiltin in SW13c1.2Vim- Cells.  Asch, W.S., and Schechter, N.  Presented at the 1998 Intermediate Filament Gordon Conference, Holderness School, Holderness NH.

Induction of the Neurofilament Proteins, Plasticin and Gefiltin, in Zebrafish Retinal Ganglion Cells after Optic Nerve Injury. W.S. Asch, D. Leake, A.K. Canger, N. Schechter.  To be presented at the 1997 Society for Neuroscience Annual Meeting.

Plasticin and Gefiltin, two novel neurofilament proteins, are expressed early in neuronal development.  Anthony Canger, Devin Leake, William Asch, Marco Passini, and Nisson Schechter.  Presented at the 1996 Cold Spring Harbor Zebrafish Development and Genetics Meeting.

Expression of Plasticin and Gefiltin during zebrafish development.  Canger, A.K., Leake, D., Asch, W.S., and Schechter, N..  Presented at the 1996 Intermediate Filament Gordon Conference, Holderness School NH.

Expression of the Neurofilament Proteins, Plasticin and Gefiltin, in the Developing Zebrafish Visual Pathway. A.K. Canger, D. Leake, W.S. Asch, E. Glasgow, and N. Schechter.  Presented at the 1996 Society for Neuroscience Annual Meeting.

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