U.S. Federal Route 35 runs east-west across this county. This route is one of the main links between Eaton and Dayton, along with Richmond, IN. U.S. Rt. 35 passes through the following towns in Preble County. New Hope Eaton Glennwood West Alexandria U.S. Rt. 35 is multi-plexed in Preble County. Interstate 70, from the Indiana/Ohio State Line to M.P. 1.
Ohio State Route 122, at Eaton. U.S. Rt. 35 intersects the following highways in Preble County. Interstate 70, near New Westville. Ohio State Route 320, near New Westville. Ohio State Route 122, at Eaton. U.S. Rt. 127, at Eaton. Ohio State Route 122, at Eaton. Ohio State Route 503, at West Alexandria.
BGS on EB I-70/U.S. Rt. 35. Juntion sign on WB U.S. Rt. 40. The interchange is actually in Indiana.
