Business U.S. Federal Route 12 runs through the City of Niles, while U.S. Rt. 12 heads around the southside on a multi-lane highway. BUSN. U.S. Rt. 12 passes through the following town in Berrien County. Niles
A guide marker on EB U.S. Rt. 12. EB BUSN. U.S. Rt. 12 on the westside of Niles. EB U.S. Rt. 12 in Downtown Niles. EB BUSN. U.S. Rt. 12/SB MI St Rt 51 at U.S. Rt. 12 on the soutside of Nile.