Missouri State Route 74 runs east-west in Southeastern Cape Girardeau County. This highway runs from Dutchtown to the Missouri/Illinois State Line, via Cape Girardeau. MO St Rt 74 passes through the following towns in Cape Girardeau County. Dutchtown Cape Girardeau MO St Rt 74 is multi-plexed in Cape Girardeau County. Interstate 55, at Cape Giradeau.
MO St Rt 74 intersects the following highways in Cape Girardeau County. Missouri State Route 25, at Dutchtown. Missouri Secondary State Route A, at Dutchtown. Interstate 55, at Cape Girardeau. BUSN Loop I-55, at Cape Girardeau. U.S. Rt. 61, at Cape Girardeau. Interstate 55, at Cape Girardeau. BUSN Loop I-55, at Cape Girardeau. U.S. Rt. 61, at Cape Girardeau. Missouri State Route 34, at Cape Girardeau.
Missouri State Route 177, at Cape Girardeau. Illinois State Route 146, at the Illinois/Missouri State Line.
A BGS on SB I-55. A BGS on SB I-55/WB MO St Rt 74. EB MO St Rt 34/74 in Cape Girardeau. EB MO St Rt 34/74 near the Mississippi River. EB MO St Rt 34/74 crossing the Mississippi River.
