Vash The Stampied - Vash is a alien who was in this program as a child where these people were takeing care of him. Then one day when they were entering the atmosphere of a planet that they wanted to colonise, his brother (Knives) blew up the ship and now Vash is on a misson to stop his brother from doing anymore damage. He also has 60,000,000,000$$ on his head because people think that he is Knives.
Meryl Stryfe - works for an insurance company that is out to stop Vash from doing any more damage. She is a fairly uptight person.
Milly Thompson - Meryl's assistant. She is a kind hearted person and very naive.
Nicholas D. Wolfwood - a priest that is out to protect or find children. He carries a cross in which he has a huge arsenal of weaponry.
Rem Saverem - a member of the crew of the ship that was going to colonize the planet. She was the person who took care of Vash and Knives on ths ship and Vash loved her.
Millions Knives - Vash's brother. He is incredibly evil and mad at the human race because the people on the ship treated him poorly.