| Captain Jack Malloy | Jarrod Emick | |
| Firefighter Erin Coffey | Christine Elise | |
| Arson Investigator Bernie Ramirez | Miguel Sandoval | |
| Battalion Chief Dick Coffey | Brian Smiar | |
| Firefighter Ray Grimes | Carlton Wilborn | |
| Firefighter Kay Rizzo | Alexandra Hedison | |
| Firefighter J. B. Baker | Brian Leckner | |
| Firefighter Lenny Rose | Michael Gallagher | |
| Firefighter Mike Durning | John Bradley | |
| Firefighter T. K. Martin | Alexandra Paul | |
| Helicopter Pilot Jed Neal | Rob Youngblood | |
| Dr. Janey Markle | Jensen Daggett | |
| Laura Malloy | Elizabeth Mitchell | |
| Flame | China Kantner | |
| Bobby Grimes | Vicellous Reon Shannon | |
| Norman Minter | Peter Crombie | |
| Detective Lou Cerone | Carmen Argenziano | |
| Brodie | Wayne Northrup | |
| Officer Ken Sundberg | Richard Joseph Paul | |
| Al Morrison | Jack Conley | |
| Firefighter Phil Regan | Kane Picoy | |
| Helen Regan | Kathryn Morris | |
| Phil Regan Jr. | Zack Duhame | |
| Megan Regan | Rachel Duhame | |
| Bobby's PD: Michelle Goldstein | Meredith Salenger | |
| Forensic Scientist Dorfman | Keith Coulouris |
| Music By | Jon Hassell [1-6] Pete Scaturro [3-6] Russ Landau [7-13] | |
| Editor | Daniel Cahn, A.C.E. [1] Michael S. Stern [2,4,6] Kaja Fehr, A.C.E. [3,5] | |
| Production Designer | Randy Ser [1-6] | |
| Director of Photography | Geoff Schaaf [1-6] | |
| Line Producer | Hal Galli [1,2] | |
| Producers | Hal Galli [1,2] Robert Papazian James G. Hirsch Harker Wade [7-13] | |
| Executive Producer | Gordon Greisman [1-13] James G. Hirsch [7-13] | |
| Co-Executive Producers | Robert Papazian James G. Hirsch Patrick Hasburgh | |
| Created By | Gordon Greisman |
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