Homing Links, Updated 12 September 2002

Assorted Homing References and Links:

12 September 2002

Lymphocyte emigration from high endothelial venules in rat lymph nodes.

Anderson AO, Anderson ND.

Immunology 31:731-48, 1976

[ This paper is the first demonstration of permeability characteristics of the High Endothelial Venule Wall that explains how polarized locomotion and chemotaxis may be involved in lymphocyte homing at high endothelial venules ]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9 92709&dopt=Abstract

Anderson, A.O. and S. Shaw. 1993. T cell adhesion to endothelium: the FRC conduit system and other anatomic and molecular features which facilitate the adhesion cascade in lymph node. Sem. Immunol. 5:271-282.

Anderson, A.O., and S. Shaw. 1995. "Lymphocyte Trafficking." Chapter 3, In Clinical Immunology, Principles and Practice. R.R. Rich, T.A. Fleisher, B.D. Schwartz, W.T. Shearer, and W. Strober (eds.), pp 39-49, Mosby-Year Book, Inc., St. Louis, MO.

Ebnet, K., E.P. Kaldjian, A.O. Anderson, and S. Shaw. 1995. Orchestrated information transfer underlying leukocyte endothelial interactions. Ann. Rev. Immunol. 14:155-177.

Gretz, E.J., E.P. Kaldjian, A.O. Anderson, and S. Shaw. 1996. Sophisticated strategies for information encounter in the lymph node: The reticular network as a conduit of soluble information and a highway for cell traffic. ("Cutting Edge") J. Immunol. 157:495-499.

Gretz, J.E., A.O. Anderson, and S. Shaw. 1997. Cords, channels, corridors and conduits: critical architectural elements facilitating cell interactions in the lymph node cortex. Immunol. Rev. 156:11-24.

Kuprash, D.V., M.B. Alimzhanov, A.V. Tumanov, A.O. Anderson, K. Pfeffer, and S.A. Nedospasov. 1999. TNF and Lymphotoxin beta Cooperate in the Maintenance of Secondary Lymphoid Tissue Microarchitecture But Not in the Development of Lymph Nodes. J. Immunol 163: 6575-6580.

Gretz, J.E., C.C. Norbury, A.O. Anderson, A.E.I. Proudfoot, and S. Shaw. 2000. Lymph-borne Chemokines and Other Low Molecular Weight Molecules Reach High Endothelial Venules via Specialized Conduits While a Functional Barrier Isolates the Lymphocyte Microenvironments in Lymph Node Cortex. J. Exp. Med. 192:1425-1440.

Kaldjian, E.P., J.E Gretz, A.O Anderson, Y. Shi, S. Shaw. 2001. Spatial and molecular organization of lymph node T cell cortex: A labyrinthine cavity bounded by an epithelial sheet of fibroblastic reticular cells anchored to basement membrane-like extracellular matrix. Intl. Immunology 13:1243-1253.

J. Exp. Med., Volume 187, Number 2, January 19, 1998 205-216

Molecular Mechanisms of Lymphocyte Homing to Peripheral Lymph Nodes

By R. Aaron Warnock, Sanaz Askari, Eugene C. Butcher, and Ulrich H. von Andrian

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9432978&form=6&db=m&Dopt=b

J Exp Med 1997 Jul 7;186(1):153-8

Polarization of chemokine receptors to the leading edge during lymphocyte chemotaxis.

Nieto M, Frade JM, Sancho D, Mellado M, Martinez-A C, Sanchez-Madrid F

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9207004&form=6&db=m&Dopt=b

Eur J Immunol 1998 Jul;28(7):2197-207

The chemokine SDF-1alpha triggers a chemotactic response and induces cell polarization in human B lymphocytes.

Vicente-Manzanares M, Montoya MC, Mellado M, Frade JM, del Pozo MA, Nieto M, de Landazuri MO, Martinez-A C, Sanchez-Madrid F

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9692889&form=6&db=m&Dopt=b

J Exp Med 1999 Jan 4;189(1):37-50

L-selectin-mediated Leukocyte Adhesion In Vivo: Microvillous Distribution Determines Tethering Efficiency, But Not Rolling Velocity.

Stein JV, Cheng G, Stockton BM, Fors BP, Butcher EC, von Andrian UH

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9874562&form=6&db=m&Dopt=b

J Immunol 1998 Dec 15;161(12):6638-47

Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin.

Steeber DA, Tang ML, Zhang XQ, Muller W, Wagner N, Tedder TF

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9862692&form=6&db=m&Dopt=b

Cell Adhes Commun 1998;6(2-3):85-96

In Situ analysis of lymphocyte migration to lymph nodes.

von Andrian UH, M'Rini C

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9823458&form=6&db=m&Dopt=b

Microcirculation 1996 Sep;3(3):287-300

Intravital microscopy of the peripheral lymph node microcirculation in mice.

von Andrian UH

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8930886&form=6&db=m&Dopt=b

J Cell Biol 1998 Feb 9;140(3):721-31

L-Selectin ligands that are O-glycoprotease resistant and distinct from MECA-79 antigen are sufficient for tethering and rolling of lymphocytes on human high endothelial venules.

Clark RA, Fuhlbrigge RC, Springer TA

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9456330&form=6&db=m&Dopt=b

J Cell Biol 1997 Oct 20;139(2):563-71

Presentation of integrins on leukocyte microvilli: a role for the extracellular domain in determining membrane localization.

Abitorabi MA, Pachynski RK, Ferrando RE, Tidswell M, Erle DJ

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9334357&form=6&db=m&Dopt=b

J Exp Med 1999 May 3;189(9):1467-1478

Lymphocyte Migration in Lymphocyte Function-associated Antigen (LFA)-1-deficient Mice.

Berlin-Rufenach C, Otto F, Mathies M, Westermann J, Owen MJ, Hamann A, Hogg N

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8219105&form=6&db=m&Dopt=b

Sci Prog 1998;81 (Pt 4):299-313

Human chemokines: role in lymphocyte trafficking.

Moser B

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10093515&form=6&db=m&Dopt=b

J Leukoc Biol 1999 Jan;65(1):6-15

Chemokines: signal lamps for trafficking of T and B cells for development and effector function.

Kim CH, Broxmeyer HE

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9886241&form=6&db=m&Dopt=b

Inflammation 1998 Dec;22(6):573-82

Activated T-lymphocytes express occludin, a component of tight junctions.

Alexander JS, Dayton T, Davis C, Hill S, Jackson TH, Blaschuk O, Symonds M, Okayama N, Kevil CG, Laroux FS, Berney SM, Kimpel D

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9824772&form=6&db=m&Dopt=b

Cell Adhes Commun 1998;6(2-3):125-33

The two poles of the lymphocyte: specialized cell compartments for migration and recruitment.

del Pozo MA, Nieto M, Serrador JM, Sancho D, Vicente-Manzanares M, Martinez C, Sanchez-Madrid F

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9823463&form=6&db=m&Dopt=b

J Immunol 1998 Nov 15;161(10):5663-72

Regulation of T lymphocyte trafficking into lymph nodes during an immune response by the chemokines macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta.

Tedla N, Wang HW, McNeil HP, Di Girolamo N, Hampartzoumian T, Wakefield D, Lloyd A

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9820547&form=6&db=m&Dopt=b

Eur J Immunol 1998 Oct;28(10):3040-7

Regulation of fucosyltransferase-VII expression in peripheral lymph node high endothelial venules.

Swarte VV, Joziasse DH, Van den Eijnden DH, Petryniak B, Lowe JB, Kraal G, Mebius RE

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9808172&form=6&db=m&Dopt=b

Science 1998 Oct 16;282(5388):480-3

Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking.

Randolph GJ, Beaulieu S, Lebecque S, Steinman RM, Muller WA

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9774276&form=6&db=m&Dopt=b

J Immunol 1998 Sep 1;161(5):2449-56

The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches.

Kunkel EJ, Ramos CL, Steeber DA, Muller W, Wagner N, Tedder TF, Ley K

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9725243&form=6&db=m&Dopt=b

Int Immunol 1998 Jul;10(7):961-8

Blockade of both L-selectin and alpha4 integrins abrogates naive CD4 cell trafficking and responses in gut-associated lymphoid organs.

Bradley LM, Malo ME, Fong S, Tonkonogy SL, Watson SR

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9701034&form=6&db=m&Dopt=b

Eur J Immunol 1998 Jul;28(7):2197-207

The chemokine SDF-1alpha triggers a chemotactic response and induces cell polarization in human B lymphocytes.

Vicente-Manzanares M, Montoya MC, Mellado M, Frade JM, del Pozo MA, Nieto M, de Landazuri MO, Martinez-A C, Sanchez-Madrid F

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9692889&form=6&db=m&Dopt=b

Eur J Immunol 1998 Jun;28(6):1959-69

Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice.

Andrew DP, Spellberg JP, Takimoto H, Schmits R, Mak TW, Zukowski MM

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9645378&form=6&db=m&Dopt=b

Biotechniques 1998 Apr;24(4):642-6, 648-51

Intracellular magnetic labeling of lymphocytes for in vivo trafficking studies.

Schoepf U, Marecos EM, Melder RJ, Jain RK, Weissleder R

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9564539&form=6&db=m&Dopt=b

Immunity 1998 Mar;8(3):373-81

Negative regulation of T cell homing by CD43.

Stockton BM, Cheng G, Manjunath N, Ardman B, von Andrian UH

http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9529154&form=6&db=m&Dopt=b

The Journal of Immunology, Vol 157, Issue 2 495-499, 1996

Sophisticated strategies for information encounter in the lymph node: the reticular network as a conduit of soluble information and a highway for cell traffic

JE Gretz, EP Kaldjian, AO Anderson and S Shaw

http://www.jimmunol.org/cgi/content/abstract/157/2/495?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=Gretz&searchid=QID_NOT_SET&stored_search=&FIRSTINDEX=&journalcode=jimmunolÂ

J. Exp. Med., Volume 187, Number 7, April 6, 1998 997-1007

The Sequential Role of Lymphotoxin and B Cells in the Development of Splenic Follicles

By Mercedes Gonzalez, Fabienne Mackay, Jeffrey L. Browning, Marie H. Kosco-Vilbois, and Randolph J. Noelle

http://www.jem.org/cgi/content/abstract/187/7/997

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J. Exp. Med., Volume 191, Number 1, January 3, 2000 61-76

The CC Chemokine Thymus-derived Chemotactic Agent 4 (TCA-4, Secondary Lymphoid Tissue Chemokine, 6Ckine, Exodus-2) Triggers Lymphocyte FunctionÂ–associated Antigen 1Â–mediated Arrest of Rolling T Lymphocytes in Peripheral Lymph Node High Endothelial Venules

Jens V. Stein^a, Antal Rot^d, Yi Luo^b, Manjunath Narasimhaswamy^a, Hideki Nakano^e, Michael D. Gunn^f, Akio Matsuzawa^g, Elizabeth J. Quackenbush^a,c, Martin E. Dorf^b, and Ulrich H. von Andrian^a,b

http://www.jem.org/cgi/content/abstract/191/1/61

J. Exp. Med., Volume 192, Number 10, November 20, 2000 1425-1440

Lymph-borne Chemokines and Other Low Molecular Weight Molecules Reach High Endothelial Venules via Specialized Conduits While a Functional Barrier Limits Access to the Lymphocyte Microenvironments in Lymph Node Cortex

J. Elizabeth Gretz, Christopher C. Norbury, Arthur O. Anderson, Amanda E.I. Proudfoot, and Stephen Shaw

http://www.jem.org/cgi/content/abstract/192/10/1425
Also see PubMed Links at: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Link&db=PubMed&dbFrom=PubMed&from_uid=11085745

The Journal of Experimental Medicine, Volume 192, Number 11, December 4, 2000 1545-1552

Follicular B Helper T Cells Express CXC Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

Dagmar Breitfeld^a, Lars Ohl^a, Elisabeth Kremmer^b, Joachim Ellwart^b, Federica Sallusto^c, Martin Lipp^a, and Reinhold Fíº‹í³´er^a http://www.jem.org/cgi/content/abstract/192/11/1545

The Journal of Experimental Medicine, Volume 192, Number 11, December 4, 2000 1553-1562

CXC Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function

Patrick Schaerli^a, Katharina Willimann^a, Alois B. Lang^b, Martin Lipp^c, Pius Loetscher^a, and Bernhard Moser^a http://www.jem.org/cgi/content/abstract/192/11/1553

The Journal of Experimental Medicine, Volume 192, Number 10, November 20, 2000 1515-1520

Requirement of the Chemokine Receptor CXCR3 for Acute Allograft Rejection

Wayne W. Hancock^a, Bao Lu^b, Wei Gao^a, Vilmos Csizmadia^a, Kerrie Faia^a, Jennifer A. King^a, Stephen T. Smiley^a, Mai Ling^b, Norma P. Gerard^b, and Craig Gerard^b http://www.jem.org/cgi/content/abstract/192/10/1515

The Journal of Experimental Medicine, Volume 192, Number 10, November 20, 2000 1521-1528

Qa-2Â–dependent Selection of CD8 ${alpha}$ / ${alpha}$ T Cell Receptor ${alpha}$ /ß¦#060;SUP>+ Cells in Murine Intestinal Intraepithelial Lymphocytes

Gobardhan Das^a, Dina S. Gould^b, Mathew M. Augustine^a, Gladis Fragoso^e, Edda Scitto^e, Iwona Stroynowski^d, Luc Van Kaer^c, Danny J. Schust^b, Hidde Ploegh^b, and Charles A. Janeway, Jr.^a http://www.jem.org/cgi/content/abstract/192/10/1521

The Journal of Experimental Medicine, Volume 194, Number 9, November 5, 2001 1361-1374

Inflammatory Chemokine Transport and Presentation in HEV

A Remote Control Mechanism for Monocyte Recruitment to Lymph Nodes in Inflamed Tissues

Roger T. Palframan¹^,2, Steffen Jung⁴, Guiying Cheng¹, Wolfgang Weninger¹^,2, Yi Luo², Martin Dorf², Dan R. Littman⁵, Barrett J. Rollins³, Hans Zweerink⁶, Antal Rot⁷ and Ulrich H. von Andrian¹^,2

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11696600&dopt=Abstract

Recirculation | Emigration at HEV | FRC Conduit | Locomotion | Chemotaxis & Links

Dendritic Cells in TDL | Dendritic cells in Tissue | Immune System Lecture Notes | Mucosal Immunity

Lymphocyte emigration from high endothelial venules in rat lymph nodes.

Molecular Mechanisms of Lymphocyte Homing to Peripheral Lymph Nodes

Polarization of chemokine receptors to the leading edge during lymphocyte chemotaxis.

Nieto M, Frade JM, Sancho D, Mellado M, Martinez-A C, Sanchez-Madrid F

The chemokine SDF-1alpha triggers a chemotactic response and induces cell polarization in human B lymphocytes.

Vicente-Manzanares M, Montoya MC, Mellado M, Frade JM, del Pozo MA, Nieto M, de Landazuri MO, Martinez-A C, Sanchez-Madrid F

L-selectin-mediated Leukocyte Adhesion In Vivo: Microvillous Distribution Determines Tethering Efficiency, But Not Rolling Velocity.

Stein JV, Cheng G, Stockton BM, Fors BP, Butcher EC, von Andrian UH

Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin.

Steeber DA, Tang ML, Zhang XQ, Muller W, Wagner N, Tedder TF

In Situ analysis of lymphocyte migration to lymph nodes.

von Andrian UH, M'Rini C

Intravital microscopy of the peripheral lymph node microcirculation in mice.

von Andrian UH

L-Selectin ligands that are O-glycoprotease resistant and distinct from MECA-79 antigen are sufficient for tethering and rolling of lymphocytes on human high endothelial venules.

Clark RA, Fuhlbrigge RC, Springer TA

Presentation of integrins on leukocyte microvilli: a role for the extracellular domain in determining membrane localization.

Abitorabi MA, Pachynski RK, Ferrando RE, Tidswell M, Erle DJ

Lymphocyte Migration in Lymphocyte Function-associated Antigen (LFA)-1-deficient Mice.

Berlin-Rufenach C, Otto F, Mathies M, Westermann J, Owen MJ, Hamann A, Hogg N

Human chemokines: role in lymphocyte trafficking.

Moser B

Chemokines: signal lamps for trafficking of T and B cells for development and effector function.

Kim CH, Broxmeyer HE

Activated T-lymphocytes express occludin, a component of tight junctions.

Alexander JS, Dayton T, Davis C, Hill S, Jackson TH, Blaschuk O, Symonds M, Okayama N, Kevil CG, Laroux FS, Berney SM, Kimpel D

The two poles of the lymphocyte: specialized cell compartments for migration and recruitment.

del Pozo MA, Nieto M, Serrador JM, Sancho D, Vicente-Manzanares M, Martinez C, Sanchez-Madrid F

Regulation of T lymphocyte trafficking into lymph nodes during an immune response by the chemokines macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta.

Tedla N, Wang HW, McNeil HP, Di Girolamo N, Hampartzoumian T, Wakefield D, Lloyd A

Regulation of fucosyltransferase-VII expression in peripheral lymph node high endothelial venules.

Swarte VV, Joziasse DH, Van den Eijnden DH, Petryniak B, Lowe JB, Kraal G, Mebius RE

Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking.

Randolph GJ, Beaulieu S, Lebecque S, Steinman RM, Muller WA

The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches.

Kunkel EJ, Ramos CL, Steeber DA, Muller W, Wagner N, Tedder TF, Ley K

Blockade of both L-selectin and alpha4 integrins abrogates naive CD4 cell trafficking and responses in gut-associated lymphoid organs.

Bradley LM, Malo ME, Fong S, Tonkonogy SL, Watson SR

The chemokine SDF-1alpha triggers a chemotactic response and induces cell polarization in human B lymphocytes.

Vicente-Manzanares M, Montoya MC, Mellado M, Frade JM, del Pozo MA, Nieto M, de Landazuri MO, Martinez-A C, Sanchez-Madrid F

Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice.

Andrew DP, Spellberg JP, Takimoto H, Schmits R, Mak TW, Zukowski MM

Intracellular magnetic labeling of lymphocytes for in vivo trafficking studies.

Schoepf U, Marecos EM, Melder RJ, Jain RK, Weissleder R

Negative regulation of T cell homing by CD43.

Stockton BM, Cheng G, Manjunath N, Ardman B, von Andrian UH

Sophisticated strategies for information encounter in the lymph node: the reticular network as a conduit of soluble information and a highway for cell traffic

The Sequential Role of Lymphotoxin and B Cells in the Development of Splenic Follicles

The CC Chemokine Thymus-derived Chemotactic Agent 4 (TCA-4, Secondary Lymphoid Tissue Chemokine, 6Ckine, Exodus-2) Triggers Lymphocyte FunctionÂ–associated Antigen 1Â–mediated Arrest of Rolling T Lymphocytes in Peripheral Lymph Node High Endothelial Venules

Lymph-borne Chemokines and Other Low Molecular Weight Molecules Reach High Endothelial Venules via Specialized Conduits While a Functional Barrier Limits Access to the Lymphocyte Microenvironments in Lymph Node Cortex

Follicular B Helper T Cells Express CXC Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

CXC Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function

Requirement of the Chemokine Receptor CXCR3 for Acute Allograft Rejection

Qa-2Â–dependent Selection of CD8/ T Cell Receptor /ß¦#060;SUP>+ Cells in Murine Intestinal Intraepithelial Lymphocytes

Inflammatory Chemokine Transport and Presentation in HEV

A Remote Control Mechanism for Monocyte Recruitment to Lymph Nodes in Inflamed Tissues

Qa-2Â–dependent Selection of CD8 ${alpha}$ / ${alpha}$ T Cell Receptor ${alpha}$ /ß¦#060;SUP>+ Cells in Murine Intestinal Intraepithelial Lymphocytes