This is a list I have compiled of great guitar players who have in one way or another redefined the shape of the music industry today. They either have a unique playing style or signature sound. Once again, these are guitarists that I have chosen based on my opinion and you are entitled to your personal preference as well.
Kirk Hammett ( Metallica)

Jimi Hendrix
Dave Matthews
Wes Borland (Limp Bizkit)

 

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